Paracetamol, ambroxol hydrochloride, levocetirizine dihydrochloride, and phenylephrine hydrochloride are used in combination for the treatment of chronic sinusitis, rhinitis, fever, nasal discharge, sore throat, and wheezing. The uv spectrophotometric method is the q - analysis (absorption ratio) method, which involves the formation of absorbance equation at 26134 nm (isoabsorptive point) and at 25300 nm the maximum absorption of ebastine. The aim of this work was to establish a procedure to estimate measurement uncertainty of a validated uv spectrophotometric method for quantification of desloratadine in tablet formulation uv spectrophotometric method was linear (r = 09972), accurate (mean recovery = 1008%), precise (rsd = 24%), and robust.
And montelukast sodium in tablet dosage form t raja1 and a lakshmana rao2 1hindu college of pharmacy, and uv detector-2998, operated at 254 nm. Tions by using uv - and hplc - hence, we made an attempt to develop a simple method for the simultaneous estimation of mon and des by rp-hplc in pharmaceutical dosage forms. Development and validation of uv spectrophotometric method for simultaneous estimation of montelukast sodium and levocetrizine dihydrochloride in bulk and tablet dosage formulation.
Determination of montelukast sodium (mtkt) and bambuterol hydrochloride (bam) in combined pharmaceutical dosage forms the principle for dual wavelength method is the absorbance difference between. The method was validated and the response was found to be linear in the drug concentration range of 50 µg/ml to 150 µg/ml for desloratadine and 50 µg/ml to 150 µg/ml for montelukast the lod and loq for desloratadine were found to be 2759, 9195 respectivly. Development and validation of uv spectrophotometric method for simultaneous estimation of montelukast sodium and bambuterol hydrochloride in bulk and tablet dosage formulation jordan journal of pharmaceutical sciences 20081(2): 152-58. Abstract wwwijipsrcom a simple, accurate, precise and economical procedure for simultaneous estimation of desloratidine and montelukast in combined tablet dosage form has been developed utilizing concept of simultaneous equation methodthe method is based upon determination of desloratidine at 269nm and montelukast at 283nm in methanol. Development and validation of spectroscopic method for simultaneous estimation of acebrophylline and montelukast sodium in combined dosage form jignesh maniya , hasumati raj , hasmukh vaghani , manoj mangukiya, pradip dudhat.
Desloratadine had no effect on fertility in rats at an oral dose of 3 mg/kg/day (estimated desloratadine and desloratadine metabolite exposures were approximately 8 times the auc in humans at the recommended daily oral dose.  goyal a, sharma cs, singh g development of uv and visible spectrophotometric methods for estimation of rupatadine fumarate from tablet formulation int j of pha res and dev 2010 2 (4) article-14. A novel, precise, accurate, rapid and cost effective isocratic reverse-phase high performance liquid chromatographic (rp-hplc) method was developed, optimized and validated for the simultaneous estimation of montelukast sodium (mon) and desloratadine (des) in pharmaceutical dosage forms. Montelukast was found to be 006 µg/ml & area 791whereas for doxofylline was 468 µg/ml & area 31651the percentage of recovery of montelukast and doxofylline was found to be 9996% and 10085% respectively.
A novel, sensitive and selective stability-indicating gradient reverse phase ultra performance liquid chromatographic method was developed and validated for the quantitative determination of desloratadine and sodium benzoate in pharmaceutical oral liquid formulation. Montelukast sodium from its potentional degradents were achieved with in shorter run time with required resolution, accuracy and precision thus enabling the utility of the method for routine analysis. Combination of montelukast sodium and desloratadine is used for rhinitis and treatment of allergies and chronic urticaria allergic rhinitis is a common chronic respiratory condition marked by sneezing and a runny and itchy nose and eyes. Abstract: two simple, fast, accurate, precise and economical uv- spectrophotometric methods have been developed for simultaneous estimation of montelukast sodium (mtkt) and desloratadine (dlor) in. Was applicable for the simultaneous determination of ambroxol and desloratadine in combined tablet dosage form the results of analysis have been validated statistically and by recovery studies.
A separation of montelukast sodium and desloratadine were achieved on ods hypersil c18 (250 mm × 46 mm, 5μ) column using a uv detector to monitor elute at 230 nm. Simultaneous estimation of fexofenadine hydrochloride and montelukast sodium in pharmaceutical dosage forms p nagaraju, g vishnu manasa, g indira priyadarshini and schvss appaji. Published: fri, 13 oct 2017 simultaneous estimation of desloratidine and montelukast in combined pharmaceutical dosage form by uv spectroscopy ettanaveen kumar, dsireesha, vasudha bakshi.
Simultaneous estimation of rupatadine fumarate and montelukast sodium by uv‐visible spectrophotometry3 literature review reveals few analytical techniques like spectrophotometry3‐8, rp‐hplc 9‐14 and hptlc 15‐16 estimations of either montelukast sodium or rupatadine fumarate. In subjects 2 to 5 years old, a single dose of 25 ml of clarinex oral solution containing 125 mg of desloratadine, resulted in desloratadine plasma concentrations similar to those achieved in adults administered a single 5-mg clarinex tablet. Rmanivannan et al/intj pharmtech res2010,2(3) 2102 hydroxydesloratadine was unaltered in subjects with impaired renal function desloratadine is a pregnancy category c drug without teratogenic effect. Lc-esi-ms/ms method  are available for the estimation of montelukast sodium in pharmaceutical preparation and in biological fluids literature survey also showed that available for the estimation of uv.